Cholangiocytes are special cells that line the small tubes (bile ducts) in the Liver. These tubes help move a fluid called bile from the liver to the intestines.
Hepatocytes are the main cells in the Liver. They play a big role in breaking down food, storing energy, and getting rid of waste.
The Liver is a large organ in our body that processes what we eat and drink into energy and nutrients. It also helps get rid of toxins and waste. It is also one of the only organs with the ability to regenerate itself.
Ascending Cholangitis is an infection that affects the bile ducts. Bacteria can travel up these ducts and cause inflammation and fever.
Drug-induced liver injury (DILI) is caused by medications that harm the Liver and especially the Hepatocytes. When these cells get damaged, it can affect how the Liver functions.
Cirrhosis happens when the liver is damaged over time, often from things like too much alcohol or certain diseases. The liver becomes scarred and can't work as well.
Ascending Cholangitis -> Cholangiocyte
Piperacillin and tazobactam are antibiotics that kill the bacteria causing the infection in the bile ducts, helping the cholangiocytes recover.
DILI -> Hepatocyte
N-acetyl cysteine is a medicine that provides the liver with important building blocks it needs to heal. For DILI, it helps protect Hepatocytes and repair the Liver.
Cirrhosis -> Liver
Carvedilol is a medicine that helps lower high blood pressure in the Liver caused by Cirrhosis. This reduces the risk of bleeding and other complications.